Formulation and In-Vitro Evaluation of Cycllophosphamide Self Nano Emulsifying Drug Delivery System

Rachana N, Ramesh K, Dr. Vijaykumar G, Kishore K
KGR Institute of Technology and Management, Rampally, Keesara, Rangareddy, Telangana, India.

A B S T R A C T
Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome, granulomatosis with polyangiitis, and following organ transplant, among other conditions. Self-nanoemulsifying drug-delivery systems offer the potential for enhancing the absorption and hence the oral bioavailability of lipophilic drugs. Cyclophosphamide SNEDDS was designed using solubility studies and phase diagram construction. A series of tests were carried out to study the effect of oil content, dilution, and drug loading on particle size. The morphology of the nano emulsion was examined with a transmission electron microscope. Subsequently, the optimized cyclophosphamide SNEDDS was investigated for in vitro release. The optimized formulation, composed of cyclophosphamide of 20.0 %, soyabean oil of 16 %, Tween 80 of 17 %, and ethyl alcohol of 17 %. The optimized formulation released 97.43 %
cyclophosphamide in 120 min.
Keywords: Self-nano emulsifying drug-delivery systems, Cyclophosphamide. etc