Wednesday , 22 May 2024

Formulation and In-vitro Evaluation of Cetylpyridinium Chloride Buccal Patch

N. Karnakar1, H. Ramana2, S. Swathi3, K.Pramod4, R. Vasanthi5
1,2,3,4Venkateshwara Institute of Pharmaceutical Sciences, Charlapally, Nalgonda, Telangana.
5School of Pharmacy, GITAM Deemed to be University, Hyderabad.

In present study buccal drug delivery of Cetylpyridinium was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route.  Matrix type of buccal patches was developed by using polymers Eudragit-L100, HPMCk4M and HPMCk15M.Buccal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be were found to be within the pharmacopeial limits, in-vitro drug release studies by using dialysis membrane. Among all the 12 formulations F6 formulation which contain HPMC K4M 300mg and Eudragit L-100 60mg had shown 94% cumulative drug release within 12 hours. And compared to HPMC K15M, HPMC K4M showed better drug release profile. For F6 formulation release kinetics were plotted and the Regression coefficient value was found to be high for Korsmeyer-peppas release model i.e., 0.9892. The n value was found to be 0.6203 which indicates the drug release pattern was found to be non-Fickian diffusion.
Keywords: cetylpyridinium, buccal, patches

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