Saturday , 20 April 2024

Formulation and In-vitro Evaluation of Atovaquone Solid Dispersions

Dr. M. Venkata Ramana1, Y. Radhika Padarthy2
1Principal, Gurram Balanarasaiah Institute of Pharmacy, Ghatkesar, Ranga Reddy–501 301.
2Research Scholar, Department of Pharmaceutics, JNTU Hyderabad, Telangana

In the current study improvement of dissolution rate, solubility and bioavailability of insoluble drug Atovaquone was done by solid dispersions prepared by using hydrophilic and lipophilic carriers. PVP, PEG 5000, Poloxamer 188 were selected as hydrophilic carriers and Gelucire 44/14 and Gelucire 50/13 were selected as lipophilic carriers to enhance the dissolution rate, solubility and hence bioavailability. Aerosil 380 was selected as inert carrier in case of solid dispersions prepared with lipophilic carriers. Ratio of drug to polymer was varied from 1:1 to 1:5. Melting and Solvent evaporation method was followed. From the results of comparative dissolution studies conducted between optimized formulations, pure drug and marketed formulations, it was concluded that formulations prepared with gelucire 44/14 (ASD 24) have shown greater drug release than remaining formulations.

Keywords: Atovaquone, Solvent evaporation method, solid dispersions.

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