G. Archana*1, Hindustan Abdul Ahad2, P. Siva Kumar1
1Department of Pharmaceutics, Gokul Krishna College of Pharmacy, Sullurpet, Nellore, Andhra Pradesh, India
2Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
A B S T R A C T
Immediate-release products result in relatively rapid drug absorption and onset of accompanying pharmaco-dynamics effects. After absorption of the drug from the dosage form is complete, plasma drug concentrations decline according to the drug’s pharmacokinetic profile. Hence greater attention is being paid on development of oral controlled release drug delivery systems. In the present study controlled release matrix tablets of Rivastigmine was formulated using different concentration of rate releasing polymers i.e. Kollidon-SR, HPMC K15M and HPMC K4M for extending the drug release up to 12 hrs. All the prepared formulations (F1-F10) were evaluated for the different physico chemical properties, which showed better results. Among all the formulations (F1-F10), it was observed that F-10 showed better dissolution profile with 94.32% drug release and followed Hixon-Crowel kinetics. Hence drug release was found to be dissolution controlled and directly proportional to cube root of time.
Keywords: Controlled drug release, Rivastigmine, Hydroxy propyl methyl cellulose (HPMC), Patient Compliance etc