Tuesday , 11 May 2021

Formulation and Evaluation of Transdermal Patches Containing Paracetamol

Author Details
Navneet Kumar Verma*1, Anubha Gupta1, Harendra Prasad2, Vikash Chandra3
1Department of Pharmacy, Rameshwaram Institute of Technology and Management Lucknow (U.P), India
2Faculty of B. Pharmacy, CSM Group of Institution, Allahabad, (U.P), India
3Dr. M.C.Saxena College of Pharmacy, Lucknow (U.P), India

It is the most important part of Pharmaceutical dosage forms; Transdermal Drug Delivery System (TDDS) established itself as an integral part of Novel Drug Delivery Systems. On the application of Transdermal patches, the delivery of the drug across dermis gives the systemic effect. Paracetamol is widely used as Antipyretics as well as mildly Analgesics. In this study Transdermal patches were prepared by Mercury Substrate Method using ethyl cellulose polymer and Poly Vinyl Pyrrolidone (PVP) was used as a plasticizer. The prepared patches was evaluated for Thickness, Folding endurance, Drug contain uniformity, Drug content, Percent Moisture Absorption and Percent Moisture loss. Average thickness was found to be 0.282mm, Folding endurance was 190, Tensile strength (2.399kg/mm2) and Drug content uniformity was found to be 9.46. In vitro permeation study was performed by using Franz diffusion cell.
Keywords: TDDS, Transdermal film, Paracetamol, Ethyl cellulose, Drug polymer, etc.

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