D. Nirmala Kumari*, R. Jagadeesh Reddy, K. Divyavani, B. Saidamma
Department Pharmaceutics, Mother Teresa Pharmacy College, Sathuapally, Khammam, Andhra Pradesh, India
A B S T R A C T
Lisinopril is the drug of choice in hypertension. Bioavailability of the drug is 25% of orally. However, its extensive first pass metabolism results in poor bioavailability. The objective of present research work is to design and evaluate the controlled release of sublingual tablets of Lisinopril to increase the bioavailability by reducing the dosing frequency. In the present work tablets were prepared using Carbopol‐934, Hydroxy propyl methyl cellulose K4M (HPMC), Poly vinyl pyrrolidine, Poly vinyl alcohol, Sodium carboxy methyl cellulose as mucoadhesive polymers, sodium saccharine was used to mask the taste of a tablet. Five formulations were developed with varying concentration of polymers. The tablets were evaluated for hardness, weight variation, thickness, percentage of drug content, Surface pH, invitro studies like swelling, mucoadhesive strength and drug release. Formulation L3 showed good mucoadhesive strength and maximum drug release of 98.7% in 1 hr. Formulation L3follows zero‐order drug release. FTIR studies showed no evidence on interaction between drug and polymers. The results indicate that the sublingual tablets of Lisinopril may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Lisinopril.
Keywords: Lisinopril, sublingual tablets, buccal tablets.