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Formulation and Evaluation of Prosopis cineraria (Linn.) Druce Phospholoipid Complex
Sangeeta Asija*1, G. Jeyabalan1, Anil Ahuja2, Rajesh Asija3
1Sunrise University, Alwar, Rajasthan, India
2Rajasthan College of pharmacy, Jaipur, Rajasthan, India
3Maharishi Arvind Institute of Pharmacy, Jaipur, Rajasthan, India
A B S T R A C T
A novel formulation of Prosopis cineraria extract in combination with the phospholipids was developed to overcome the limitation of absorption and bioavailability. The aim of this study was to prepare and characterize Prosopis cineraria phytosomes. Prosopis cineraria phytosomes was prepared to improve the lipophilic properties of Prosopis cineraria extract. Phytosomes were prepared by rotary evaporator method. The physicochemical properties of the phytosomes including infrared spectrophotometry, % yield, solubility and apparent partition coefficient were determined. In addition, drug content and in vitro dissolution was evaluated. The results of infrared spectra showed that there was some interaction between drug (Prosopis cineraria methanolic exract) and phospholipid (soya lecithin) in the complex (phytosomes), but no new characteristic absorption peaks were observed, indicating that no new covalent bonds were formed. Compared with native Prosopis cineraria methanolic extract, the physicochemical properties of Prosopis cineraria methanolic extract was changed significantly after it was complexed with phospholipid. These characteristics, especially the improved higher lipid solubility, will contribute to the improved oral absorption of Prosopis cineraria extract.
Keywords: Prosopis cineraria, Phytosomes, Methanolic extract, Phospholipid
