Tuesday , 5 March 2024

Formulation and Evaluation of Pitavastatin Nanoparticles

T. Satyanarayana*1, K. Someshwar2
1Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana, India.
2Managers, Formulation R&D, KP Labs (A Division of KDPL), Kothapet, Hyderabad, Telangana, India

Nanoparticles can be used for the targeting of anti low density lipoprotein used in treatment of dyslipidemia, thereby achieving major benefits such as reduction in total dose and avoidance of systemic toxicity and other side effects. Nanoparticles were prepared by solvent evaporation technique and characterized by particle size analysis, drug entrapment efficiency, SEM, in vitro evaluation studies. In vitro release studies were performed in Franz diffusion cell using dialysis membrane in phosphate buffer solution of pH 6.8. The kinetics of release was determined and fitted to an empirical equation. At highest speed the resultant Nanoparticles were smaller in size and their size increased with increase in lipid concentration. Nanoparticles were obtained with polymers like Eudragit RL-100, Ethylcellulose, PVP-K30 different ratios. Pitavastatin Nanoparticles showed maximum entrapment efficiency and controlled release. Nanoparticles prepared with stearic acid showed maximum release. The in-vitro release was found to follow Non- Fickian Diffusion mechanism. The surface characters were found to be better with all the lipid carriers. All the formulations showed significant inhibition and anti-inflammatory properties. Pitavastatin loaded Nanoparticles can be prepared by solvent evaporation method with narrow size range, high entrapment efficiency with better stability. The formulation showed better of anti low density lipoprotein used in treatment of dyslipidemia.
Keywords: Nanoparticles, Pitavastatin, Particle size, SEM, in vitro evaluation studies.

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