P. Amani1, K. Sunil Kumar2
1Department of Pharmaceutics, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
2Associate Professor, Department of Pharmaceutics, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
A B S T R A C T
The aims of the present work are to prepare and evaluate controlled release Pitavastatin Direct compression technique with different compositions of excipient. Nine formulations were prepared by using polymer different grades of hydroxyl propyl methyl cellulose, ethyl cellulose, xantham gum. The in vitro drug release studies of Pitavastatin controlled release tablet was aimed at 12 hrs release. The dose of controlled release dosage form of Pitavastatin tablet was 5m. Pitavastatin a lipid-lowering agent that belongs to the statin class of medications for treatment of dyslipidemia. It is also used for primary and secondary prevention of cardiovascular disease. Based on the results indicated that, there was no interaction between the drug substances and the chosen excipients and hence these excipients were considered for the use in the development of the formulation. The controlled tablets of an optimized formulation F9was prepared by using polymers of HPMC K 15 M by direct compression technique.
Keywords: Pitavastatin, Direct compression technique, In-vitro drug release, Controlled release, Formulation