Formulation and Evaluation of Insitu gelling System for Ocular delivery of Timolol Maleate

ABOUT AUTHOR
Prathima Sirisuru*, Prathyusha Sirisuru, Parvathi M
Ragavendra Institute of Pharmaceutical Education and Research, Anantapur, A.P, India.
*E-mail: [email protected]

Abstract
Poor bioavailability of ophthalmic solutions caused by dilution and drainage from the eye can be overcome by using insitu forming ophthalmic drug delivery system prepared from polymers that exhibit reversible phase transitions from liquid to gel. This results in better ocular availability of drug. The purpose of this work was to develop an ophthalmic drug delivery system on the concept of ion activated insitu gelation for Timolol maleate, an antiglaucoma agent. sodium alginate which gels in the presence of divalent cations present in lacrimal fluid was used as gelling agent HPMC, HEC, HPC Incorporated as the viscosity enhancing agent. The promising formulation F6 showed viscosity 44.2cps at 12rpm.99.72% drug release at the end of 8hrs.The developed formulations were therapeutically effective, stable, non annoyance and provided sustained release of drug over an 8 hrs period. The system is thus a viable alternative to conventional eye drops.
Keywords: Timolol maleate, insitu gelation, ophthalmic drug delivery, Sustained release