Formulation and Evaluation of Immediate Release Fluconazole Tablets for the Treatment of Fungal Infections

B. Venkateswara Reddy*, P. Naga Haritha
Department of Pharmaceutics, St. Paul’s College of Pharmacy, Turkayamjal (V), Hayathnagar (M), R.R.Dist-501510, India

A B S T R A C T
In the present study immediate release tablets of fluconazole have been developed which is used for the treatment of various fungal infections. Fluconazole is having longer half life thus a delivery system is designed to release the drug in short period of time, thereby enhancing the dissolution and bioavailability. Formulations have been developed using different concentration of various disintegrants by direct compression method. Initially the powder blend was evaluated for micromeritic properties and found to have good flow properties. The results of post compression studies were satisfactory. Formulation containing Ac-di-sol was found to be better in terms of wetting time, disintegration time and dissolution time when compared to other formulations and is thus optimized.
Keywords: Immediate release tablets, Fluconazole, Disintegrants, Ac-di-sol.