Formulation and Evaluation of Fast Dissolving Tablets Salmeterol

ABOUT AUTHOR
Shikhar Baboo*, B.U. Jhansi, S.K Jain
Department of Pharmaceutics, Bundelkhand University, Jhansi, U.P, India.
*E-mail: [email protected]

Abstract
Recently fast dissolving drug delivery system have started gaining popularity and acceptance as one such example with increased consumer choice, for the reason of rapid disintegration, dissolution, self-administration even without water or chewing. Asthma is a chronic disease of the respiratory system in which the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus and difficulty in breathing. So the action of drug should be very quickly. The parentrals and aerols have rapid action but its side effect more and patient can become addict to these type of dosage form. So reduce these type of complicance. Fast dissolving tablet of salmeterol  play great role in treatment asthma and chronic obstructive pulmonary  disease.Salmeterol is a strong bronchodilator .So the fast dissolving tablet of salmeterol so rapid onset of action with the use of superdisintegrant such as crospovidone, primojel. Various techniques are available for prepaing fast dissolving tablet. But the tablets were prepared by direct compression method because in this method tablets are compressed directly from powder mixture of API and suitable excipients. No pretreatment of the powder blend by wet or dry granulation procedure is required.
Key words: fast dissolving tablet, salmeterol, superdisintegrant, direct compression.