Friday , 21 June 2024

Formulation and Evaluation of Amphetamine Sublingual Tablets

G. Sirisha*1, Poreddy Meghana Reddy1, B. Haritha1, Bandari Deepika1, Veerla Jyothi1, Vagdevi Yerramsetty2
1Bojjam Narasimhulu Pharmacy College, Sayeedabad, Hyderabad, Telangana-500059.
2KP Labs, kothapet, Hyderabad-500035

In the present work, an attempt has been made to develop Sublingual tablets of Amphetamine. In the present work Sodium starch glycollate, Cross povidone and Crosscarmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 99.16 % in 8 min hence it is considered as optimized formulation. The F4 formulation contains Cross Povidone as super disintegrate in the concentration of 5 mg.
Keywords: Amphetamine, sodium starch glycollate, Cross povidone and Cross carmellose sodium.

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