Ramesh Naik M*, Hindustan Abdul Ahad, Ishaq B Md
PG Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
The main target of the present investigation was to prepare Montelukast sodium matrix tablets by using Hibiscus rosa-sinensis leaves mucilage for its release retardant bustle. Hibiscus rosa-sinensis leaves were characterized for physicochemical assets. Diverse matrix tablets were prepared by wet granulation technique. The prepared matrix tablets found to have good pre-compression and post compression parameters. The swelling performance, release rate features and the in vitro dissolution study displayed that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix former in tablets. The drug release kinetics from optimized F-5 formulation showed zero order release. The study concludes that Hibiscus rosa-sinensis leaves mucilage can be used as aproficient matrix forming polymer, to retard the release of Montelukast from the tablets.
Keywords: Montelukast sodium, Hibiscus rosa-sinensis, matrix tablets, sustained release