N. Kalpana Devi1*, Chandrika Dontha2, D.S.S.N. Neelima3
1,2Teegala Krishna Reddy College of Pharmacy, Hyderabad, Telangana State
3Vikas Institite of Pharmaceutical Sciences, Rajahmundary
A B S T R A C T
The aqueous extract of Borassus flabellifer fruit pulp was tested for its anti-epileptic action at 200 mg/kg and 500 mg/kg using the standard drugs phenytoin (for MES) and valproic acid (for PTZ) and the results were compared with those of control and standard groups. The important parameters studied were seizure latency (in PTZ method only), tonic hind limb flexion, tonic hind limb extension, clonus, post-ictal depression and recovery or death of the mice. The abolition of tonic hind limb extension was considered as a convenient end point (suggestive of protection against MES and PTZ seizures). In the present study, the test compound has shown protection against both MES and PTZ seizures at a dose of 500 mg/kg. Since tonic-clonic convulsions are the clinical correlates of MES seizures and absence seizures correlate with PTZ seizures, the aqueous extract of Borassus flabellifer fruit pulp is likely to be of use in the management of tonic-clonic and absence seizures.
Keywords: Borassus flabellifer, anti-epileptic, Phenytoin, valproic acid.