CH. Rajya Lakshmi Swetha1*, I. Rakesh2, K. Hema Priya3, P. Tirumala4, R. Kiseela5, Y Pavan kalyan6
1Associate Professor, Department of Pharmacology, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
2,3,4,5,6 Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
A B S T R A C T
The present study was designed to evaluate Memory enhancing and antistress activity of ethanolic extract of Garcinia indica aerial parts (GIE).The hypotheses is that this drug can enhance the cognitive function in different regions of the brain and decrease the psychological & physical stress and stress related disorders too. Garcinia indica is used as cardiotonic, an appetizer, a good liver tonic, for improvement of peristalsis, anthelmentic, antiulcer and antitumour. To study its Memory Enhancing effect the amnesia was produced using Scopolamine induced amnesia model in which Scopolamine disrupted the acquisition, retention and consolidation of a learned task. For screening of anti stress activity of GIE stress was induced by immobilization induced stress model which causes physical as well as psychological stress. Data obtained from the study significant dose dependent neuro-protection, memory enhancement and adaptogenic activity of GIE which might also be useful as supportive adjuvant in treatment of elderly memory loss, stress and stress related disorders.
Keywords: Anti stress, Garcinia indica, Scopolamine, Neuroprotection, Memory enhancement