Hussain Basha M*, Nagesh Kuruba, Nageswaraiah B, Nagaraju B
Sri Lakshmi Venkateswara College of Pharmcy, Proddatur, Kadapa, Andhra Pradesh, India.
A B S T R A C T
With the advances in the field of science and technology, came the mostly used drugs of the day, the synthetic drugs. Though effective they possess side-effects and sometimes life threatening adverse effects. Hence, during the past several decades there has been a global trend for the revival of interest in the traditional system of medicine. Simultaneously, the need for basic scientific investigations of medicinal plants using indigenous medical systems has become more interesting and relevant. In the absence of reliable liver protection drugs in modern medicine, in our review of literature, we found that a plant “Nelumbo nucifera” contains alkaloids and flavonoids as the major chemical constituents and thus has the hepatoprotective and antioxidant potential. Taking the above information into consideration this study is undertaken to evaluate the hepato protective and antioxidant activities of “Nelumbonucifera” flowers in wistar albino rats. To evaluate this hepato protective activity need to prepare the ethanolic and aqueous flower extracts of Nelumbo nucifera (EENN and AENN respectively) and for evaluation of the in vitro antioxidant activity of ethanolic and aqueous extracts of Nelumbonucifera flowers in rats by different methods.
Keywords: Extended release, Eudragit polymers, Wet Granulation, Korsemeyer-peppas, diffusion, Erosion.