About author :
Naveen Kumar B*, Hindustan Abdul Ahad, Thippeswamy M,
Sreeramulu Naik S, Anuradha CM, Anil Kumar K
Balaji College of Pharmacy, Anantapur, Andhra Pradesh, India
Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India
The present study was aimed to explore the diuretic actions of n-butanol extract of Allium cepa bulbs in male Westar albino rats. The n-butanol extract of Allium cepa was administered at three doses (10, 20 and 30 mg/kg, p.o.) to wistar rats in the present diuretic model. Furosemide, a standard diuretic was used as reference drug. In this study urine volume and urine electrolyte levels were determined. The extract gave positive tests for Alkaloids, Cardiac glycosides and Saponins, steroids. The n-butanol extract of Allium cepa bulbs increased urine volume and urine electrolytes excretion with a dose of 20 mg/kg, p.o. The study concludes that n-butanol extract of Allium cepa bulbs possesses the acute diuretic activity, thus validating the traditional use of this plant as diuretic. However further studies are necessary to isolate and characterized the phytoconstituents responsible for diuretic action and to explore the exact underlying mechanism of Allium cepa bulbs.
Key words: Allium cepa, diuretic, Furosemide