Monday , 17 June 2024

Evaluation of Antipsoriatic activity from Azadirachta indica leaves by Ethanolic extract in Wistar rats

Yalamuri Chandravadana, Karamala Swetha
Department of Pharmacology. Krishna Teja Pharmacy College, Chadalawada Nagar, Tirupathi-517506, Chittoor (DT), A.P.

Psoriasis is a chronic autoimmune and noncommunicable inflammatory disease of skin and joints. The disease has a worldwide prevalence of two percent, with a higher prevalence of about 4.6% in developed countries. It is characterized by having sharply demarcated scaly, red, coin-sized skin lesions most often on the elbows, knees, scalp, hands and feet.  Number of herbal plants were evaluated for anti-psoriatic activity and documented. Traditionally, Azadirachta indica leaves were used for various skin diseases and especially for psoriasis. Mouse tail test and UV radiation induced psoriasis were used for the evaluation of antipsoriatic activity. Extracts were tested at a dose of 100 mg/kg b.w. and fractions at 200 mg/kg b.w. in Wistar rats. The present study supports the use of ethanolic extract of Azadirachta indica at dose   level of 200 mg/kg  for psoriasis treatment..
Keywords: Psoriasis, UV -Ray, Azadirachta indica, ethanolic extract.

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