Friday , 11 October 2024

Evaluation of Adverse Drug Reactions in General Medicine Department of a Tertiary Care Hospital: A Cross-sectional study

Kiran Kumar Chemudugunta*1, Dr. Habib Habibuddin M2
1Research Scholar, Rayalaseema University, Kurnool, Andhra Pradesh, India
2Principal, Shadan College of Pharmacy, Hyderabad, Telangana, India

A  B  S  T  R A C T
Background: In hospital settings, Adverse Drug Reactions (ADRs) are the major cause for the increased length of hospital stay, cost, morbidity and mortality. The study aim to evaluate the incidence, risk factors, prevalence of the ADRs in Hospital. Materials and methods: This is prospective, cross-sectional study conducted in general medicine department of a tertiary care referral hospital located in Hyderabad, Telangana, India. All patient related data was collected by using a suitably designed data collection form. Any untoward event after administration of the drug was labeled as adverse drug reaction after discussing with concerned physician. Descriptive statistics were used to represent socio-demographic, clinical, and ADR profile of the study participants. Results and Discussion: A total of 412 patients were recruited from the general medicine department of the hospital, among these patients 114 ADRs are observed and documented. Age more than 60 years was strongly associated to develop ADRs. The major organ system affected due to ADRs are as follows, skin (37; 32.4%), gastro intestinal tract (26; 22.8%), and cardiovascular system (10; 8.7%). ADRs are also affected other organ system like Liver, blood, central nervous system, kidney, respiratory system and body. The most common drugs involved are Antibiotics and NSAIDs. Conclusion: The study concludes that, the ADRs appeared in this study are moderate in nature where there is no harm to the patient. This study had improved the acceptance of ADRs caused by the drugs and also given interventions on case to case basis.
Keywords: Icariin, Partial sciatic nerve ligation, Neuropathic Pain

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