Tuesday , 16 July 2024

Evalaution of Antihyperlipidemic Activity of Tephrosia Purpurea Plant Extracts in Mice

Dr. T. Satyanarayana*, L. Krishnaveni, Alla Nrayanarao, Adapa Satish kumar and G. Sabari
Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India

The Present Study is to Evaluate the Anti-Hyperlipidemic Activity of Tephrosia Purpurea Extracts on Triton X-100 induced Hyperlipidemic mice. The mice were divided in to six groups containing four animals in each group. Group – I: Normal Control. (Normal saline 10ml/kg orally for 7 days). Group – II:  Hyperlipedemic control, (Triton x 100.) Group – III: Hyperlipedemic mice treated with METP at dose of 500mg/kg. for 7days. Group–IV: Hyperlipedemic mice treated with PETP at dose of 400mg/kg for 7days. Group – V: Hyperlipedemic mice treated with PETP at dose of 500mg/kg. for 7days. Group–VI:  Hyperlipedemic mice treated with Atorvostatin at 10 mg/kg for 7days. All the groups receives single i.p. injection of Trition X-100 at dose of 100mg/kg, simultaneously with Group-II, to Group–VI, expect Group I (Normal control). After 72 hours of Triton X-100 injection. The Group – VI receives Atorvostatin at dose of 10 mg/kg for 7 days. The Group– III, receive METP, at a dose of 500mg/kg for 7 days and Group – IV, Group – V recives PETP at a dose of 400mg/kg and 500mg/kg for 7 days. On 0th day and 8th day mice are anesthetised and blood sample is collected   from retro-orbital plexus of rat using micro capillary technique from mice of all the groups, and centrifuged at 3000 rpm for 15 min so as to get serum. The serum is analyzed for total cholesterol, triglycerides and HDL levels using biochemical kits. VLDL-C and LDL- Cholesterol were calculated by the formula.  

Keywords: Anti-Hyperlipidemic, Triton X-100, PETP (Phenolic Extract of Tephrosia Purpurea), METP (Methanolic Extract of Tephrosia Purpurea), Atorvostatin

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