Saturday , 25 May 2024

Development, Optimization & Characterization of topical Nanoemulsion Gel of an Antifungal Agent for Effective Treatment of Onychomycosis

Umesh Yadav*, S.K Prajapati, R.N Prajapati, Reena Singh
Institute of Pharmacy, Bundelkhand University, Jhansi, U.P India-284128
*E-mail: [email protected]

Onychomycosis is a fungal infection of the keratinized tissue of the nail plate that is notoriously difficult to diagnose and treat Onychomycosis is a disease involving very difficult treatment mainly because it presents a poor response to available drugs thus treatment is frequently discontinued by patients This disease is a therapeutic challenge determined by nail-substratum anatomical characteristics and due to disease chronic it. The scientist has been using different new delivery system to treat the disease. The new drug delivery system contains nanoemulsion gel iontophoretic system. The other systems are nanoparticles, nanoemulsion, carrier system (liposome, niosome, erythrosome and dendrimers).The nanoemulsion gel is a novel approach to treat the onychomycosis. The onychomycosis is a local candidal infection. The treatment of onychomycosis is quit challenging as it is very difficult to cross nail plate. The selection of antifungal agent is also play a very important role. Clotrimazole shows very potent action on the candida. Clotrimazole is a newer antifungal agent which kills candida very effectively. The molecular weight of clotrimazole is also very low. It is suitable for the topical application. The solubility of the clotrimazole is BCS class 2nd drug. The solubility of the clotrimazolean is increased by nanoemulsion the drug entrapped inside the oil phase.
Keywords: B Nanoemulsion, Clotrimazole

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