Development of Novel Controlled Release Buccoadhesive Drug Delivery Anti-Diabetic and Anti-Inflammatory Drug Combination

About author
*Hindustan Abdul Ahad², Anuradha CM¹*, Abhilash A², Prabhuraj KJ², Swapna K², Anil Kumar K^2
1Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India
²Department of Pharmaceutics, Balaji College of Pharmacy, Anantapur, Andhra Pradesh, India
* e-mail : [email protected]

ABSTRACT
The present research work was aimed for an innovative study to prepare buccoadhesive tablets of Glipizide and Valdecoxib with unidirectional release. In this study buccoadhesive bilayer tablets were prepared with a core layer and a backing layer. The prepared tablets were characterized for physical parameters viz., thickness, weight variation, hardness, friability, uniformity in drug content, surface pH, water absorption, mucoadhesive performance, in vitro dissolution and in vivo studies. The fabricated mucoadhesive tablets showed good physical appearance and passed the weight variation test as per I.P specifications. The hardness and Friability of the prepared tablets indicates the compactness and mechanical strength. The uniformity in drug content in the formulated tablets indicates that the drugs were uniformly mixed with the polymers used.  The surface pH of all formulated mucoadhesive tablets was almost within the salivary pH range. The water absorption studies revealed that the formulated mucoadhesive tablets with Sodium CMC exhibits high percent water absorption as compared to formulations with Poly Vinyl Pyrrolidone. The in vitro dissolution studies revealed that the release rate of Glipizide and Valdecoxib was maximum from the mucoadhesive tablet made with Carbopol 940 and PVP. The kinetic data showed that the drug release from, formulations was mainly due to diffusion and erosion mechanism. The GPV-5 formulation showed hypoglycemic actions and in vivo drug release. The accelerated stability studies revealed that GPV-5 formulation retained the physicochemical properties even after the stressed storage conditions.
Key words: Glipizide, Valdecoxib, buccoadhesive tablet, evaluation