Saturday , 25 May 2024

Development & In-Vitro Characterization of candesartan Muco-Adhesive Buccal Tablets

Dr. R. Srinivasan, M. Geetavani*, J. Kamal Chandra, D. Rajesh Kumar, K. Sucharitha
Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, Andhra Pradesh, India.

Mucoadhesive drug delivery systems are the systems which utilize the property of mucoadhesion of certain polymers, which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended period of time. Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Nine different formulations were prepared by using different constituents. Then the tablets were evaluated for various physicochemical properties and stability. They were also evaluated for in vitro drug release, swelling index and release kinetics. Among all the formulations, the F6 formulation with API and Carbopol 934 in the ratio of 1: 7 exhibited significant moisture absorption properties with optimum release profile.  
Keywords: Mucoadhesive drug delivery systems, Candesartan, swelling index, Carbopol-934

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