B. Naveena, V. Saichitra Prathyusha*, D. Manasa, K. Deepthi, P. Prathyusha
Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore, A.P, India
A B S T R A C T
Hypertension is currently affects, approximately one billion adults globally. It is a major risk factor for cardiovascular diseases (CV) and stroke. The high prevalence of hypertension has contributed to the present pandemic of CV disease, which now accounts for 30% of all deaths worldwide. As the population ages and the prevalence of contributing factors such as obesity, sedentary lifestyle and smoking rise, this figure is projected to increase by 60% to 1.56 billion by the year 2025. The present study was to compare the efficacy of Amlodipine vs. Atenolol, both are belongs to the above mentioned classes of channel blocker and beta adrenergic blocker above Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure and Atenolol will reduce the heart rate, blood pressure and decreases myocardial contractility. Treatment of hypertension with two study drugs Amlodipine 5 mg and Atenolol 25 mg were carried out in a population of 50 patients. They were instructed to follow a healthy diet with proper exercise. After 3 months study it is observed that, both of the study drugs have good impact on blood pressure lowering. But the Atenolol 25 mg showed superior reduction in blood pressure when compared to Amlodipine 5 mg.
Keywords: Hypertension, Myocardial contractility, Atenolol, Family history