Saturday , 22 June 2024

Biochemical Studies on Antidiabetic Effect of Papaverine Psychosis Associated Diabetes Mellitus in Sprague-Dawley Rats

Sravani Batchu*, E. Bhavya
VISTAS Vels University, Department of Pharmacy, Pallavaram, Chennai
VISTAS Vels University, Department of Pharmaceutical Sciences, Pallavaram, Chennai

A  B  S  T  R A C T
Papaverine is an opium alkaloid of the benzylisoquinoline group, of low toxicity and non-habit forming. It is used in the treatment of conditions associated with smooth muscle spasm. PDE-10A expressed in the striatum and subsequent increase in cAMP and cGMP after PDE-10A inhibition by a selective inhibitor like papaverine, is a novel therapeutic avenue in the discovery of antipsychotics. The present study is undertaken to assess the effect of papaverine on psychosis associated diabetes mellitus. In this study, male Sprague dawley rats are taken and divided in to four groups viz., control, negative control, and two different doses of test drug (10mg/kg, i.p and 20mg/kg, i.p). High fat high sucrose diet for a period of 6 weeks and weekly once administration of apomorphine (1mg/kg, s.c) is used to induce diabetes and psychosis. Papaverine treatment is started on 21st day after confirmation of elevated blood glucose levels which indicates state of diabetes. The treatment period is continued till the end of the study. The biochemical parameters are evaluated by Lipid profile, Glucose, Glycosylated haemoglobin, SOD, Total protein; CAT, GSH, and MDA are measured. Treatment with papaverine at two different doses significantly exhibited antipsychotic and antidiabetic effects on HFHSD and Apomorphine induced rats.
Keywords: Papaverine, Apomorphine, Diabetes mellitus, Insulin Resistance, Phosphodiesterase (PDE) inhibitor, High fat-high sucrose diet (HFHSD), Psychosis.

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