Wednesday , 17 August 2022

Antidiabetic Potential of Insulin Plant (Costus igneus) Leaf Extracts in Streptozotocin-Induced Diabetic Rats

Choudhary Urmila*1, Soni N.D1, Rajnee1,Purohit A.K2, Choudhary Sunita1, Maheshwari R. K3
 1Department of Physiology, Dr. SN. Medical College, Jodhpur, Rajasthan, India.
2Director of Rajasthan Knowledge Center, Jodhpur, Rajasthan, India.
3Department of Chemistry, SBRM Govt. PG College, Nagur, Rajasthan, India

A B S T R A C T
Costus igneus, Insulin plant is a medicinal plant and capable of having magic cure for Diabetes. Leaf of this herbal plant helps to build up insulin by strengthening β–cells of pancreas in the human body thus popularly known as “Insulin plant” in India. Objective: The present research study was carried out to investigate the antidiabetic potential of aqueous and methanolic extracts of different doses of Costus igneus plant leaves. Healthy male albino rats weighing about (150-220) g were selected for the present investigation. Diabetes was induced in rats by intraperitoneal injection of streptozotocin given at a dose of (45mg/kg, body weight). Normal Control, Diabetic Control, Diabetic rats treated with Glibenclamide (0.5mg/Kg body weight) and Diabetic rats treated with aqueous extract of Costus igneus (AEC) of different doses AEC50, AEC100 and AEC200 (mg/Kg BW) and methanolic extract of Costus igneus (MEC) of different doses MEC50, MEC100 and MEC200 (mg/Kg BW) in one month study. Induction of diabetes with STZ (45mg/Kg BW) significantly increased the blood glucose (p<0.001) of the animals in the diabetic control group. The diabetic rats that were treated with glibenclamide and different doses of aqueous and methanolic extract of Costus igneus leaves, showed a significant decrease in the blood glucose level. Aqueous and methanolic extracts of Costus igneus leaves exhibited antidiabetic potential. The methanolic extract was more effective than aqueous extract.
Keywords: Costus igneus, hyperglycemia, insulin plant, STZ

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