Saturday , 20 July 2024

Antidiabetic Activity of Methonolic Extract of Eugenia jambolana Seeds and Cinnamomum zeylanicum bark on Alloxan Induced Diabetic Rats

K. Jyothsna Jayaraju*, E. Vani, K. Mahammad Rafiq, T. Aishwarya Venugopal, E. Archana
St. Johns College of Pharmaceutical Sciences, Yemmiganur, Kurnool dist, Andhra Pradesh.

Eugenia jambolana (EJ) and Cinnamomumzeylanicum (CZ) are used comprehensively in the indigenous system of medicine as anti-diabetic agents. The aim of the present work is to study the combined action of Methanolic extract of Eugenia jambolana and Cinnamomumzeylanicum (EJ+CZ)on blood glucose levels in alloxan induced diabetic albino rats. Rats were injected intraperitonially with alloxan monohydrate at a dose of 150mg/kg to elevate the blood glucose levels. Rats with blood glucose levels more than 200mg/dl were considered hyperglycemic and were selected for the study. Following the treatment with combination of(EJ+CZ)at various doses of100mg/kg, 200mg/kg, 400mg/kg to the animals, the blood samples were collected and blood glucose levels estimated. Both the plants in combination, succeeded in lowering blood glucose levels in rats, moreover 28 days treatment with combination of both herbs significantly reduced blood glucose level. It can be concluded that Eugenia jambolana and Cinnamomumzeylanicum combination can be used as natural blood glucose lowering agent.
Keywords: Eugenia jambolana, Cinnamomumzeylanicum, Alloxan, Diabetes Mellitus.

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