Monday , 26 February 2024

Anti-Depressant Activity of Alstonia Venenata R.Br Stem Bark Extracts in In-vivo Methods

C. Pradeep Kumar*, T. Sravanthi, Dr. Vijaya Kuchana, CH. Maheswara Reddy
Teegala Krishna Reddy College of Pharmacy, Hyderabad, Telangana, India

A B S T R A C T
The ethanolic extract of Alstonia venenata R.Br stem bark was subjected for phytochemical investigation and LD50 studies. It was found that ethanolic extract contained reducing sugars, proteins. Aminoacids, flavonoids, phenolic compounds and tannins. Phenolic compounds and flavonoids are responsible for anti-depressant activities. The extract was tested for their lethal effect up to the dose level of 1000mg/kg. No mortality was observed in mice. The administration of extract at doses of 50mg/kg, 100mg/kg, by oral administration, produced a significant (P<0.05-0.01) anti-depressant effect in mice by Tail Suspension Test and Forced Swim Test of 50mg/kg by oral administration, significantly (P< 0.05- 0.01) produce. Further studies are necessary to confirm and extend the results.
Keywords: Alstonia venenata R.Br stem bark, soxhlet apparatus, Mice, Tail Suspension Test, Forced Swim Test.

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