Harnish Patel*1, Priyanka Patel2, Patel Chirag J3, Ramesh Dhani4
1Director, Research Scholar Hub, Gujarat.
2Managing Editor, IJPRBS, Gujarat.
3Dept. of Pharmaceutics, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, Rajasthan, India
4Dept. of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, Nellore, A. P, India-524346
Various approaches have been worked out to improve the retention of oral dosage form in the stomach like floating systems, swelling and expanding systems, bioadhesive systems, high density systems. Gatsroretentive drug delivery system offers several advantages besides providing better bioavailability to poorly absorbed drugs and a required release profile thus attracting interest of pharmaceutical formulation scientists. Floating microspheres (Hollow Microspheres) are gastro-retentive drug delivery systems based on non-effervescent approach. Hollow microspheres are in strict sense, spherical empty particles without core, free flowing powders consisting of proteins or synthetic polymers, ideally having a size in the range 1-1000 micrometer. Floating microspheres are characterized by their micromeritic properties such as particle size, tapped density, compressibility index, true density and flow properties including angle of repose, scanning electron microscopy, in vitro floatability studies, in vivo floatability studies, in vitro drug release studies and stability studies etc.
Keywords: Floating Microspheres, Gatsroretentive, Hollow Microspheres, Absorption