Saturday , 8 May 2021

A Noval Approach of Fast Dissolving Films: A Review

B. Ramesh*, K. Saravanakumar, K. Jagadish kumar, SK. Saddham hussain
Department of pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India

Abstract
The main objective of proposed work is to enhance the bioavailability of selective drug by rapid dissolving films techniques. Rapidly dissolving films (RDF) are the most advanced form of oral solid dosage form due to more flexibility and comfort. It improves the efficacy of active pharmaceutical ingredients (API) by dissolving within minute in oral cavity after the contact with saliva without chewing and no need of water for administration. Rapidly dissolving films also have an established shelf-life of 2-3 years depending on the API but are extremely sensitive to environmental moisture. The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients. Eventually, film formulations having drug will be commercially launched using the RDF technology. Excipients are film forming polymers, plasticizers, sweetening agents, saliva stimulating agents, flavorings and colouring agents. Various methods are available for the preparation of rapid dissolving films such as solvent casting, hot melt extrusion, semisolid casting, solid dispersion extrusion and rolling method. Characterization parameters for rapidly dissolving films are thickness, appearance, weight variation, disintegration time, drug content, tackiness, surface pH. .
Keywords: surface pH, Excipients, Rapidly dissolving films, colouring agents.

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