Tuesday , 21 November 2017

Synthesis and Characterization of New Di Phenyl Quinoxaline Derivatives

C. Ramakrishna*, G. Saikrupa, S. Hanumantha rayappa, V. Visnu kumar, B. Swapna, S.Brahmani Bai, Dr. M. Geetha vani
Balaji College of Pharmacy, Department of Pharmaceutical Chemistry Ananthapuramu, A.P, India.

A B S T R A C T
The heterocyclic compounds are very much used as anti microbial agents. Quinoxalines are an important class of nitrogen containing heterocyclic with wide variety of biological activities. Quinoxaline ring is a part of various antibiotics, such as Echinomycin, Levomycin and Actinoleutin that are known to inhibit growth of gram positive bacteria and are active against various transplantable tumors The application of microwave irradiation is used for carrying out chemical transformations, which are pollution free, and eco- friendly and this method is superior to conventional method. These are the building blocks for the synthesis of anion receptor, cavitands, dehydroannulenes, and DNA cleaving agents their diverse pharmacological and biological properties, have emerged as privileged structures in combinatorial drug discovery libraries. Quinoxaline itself is prepared by the reaction of o-phenylenediamine and glyoxal. 1a, 1b are active as GPCR ligands, ion channel modulators, kinase inhibitors, nuclear receptor ligand and enzyme inhibitor. Several methods for synthesis are available in literature which involves conventional one pot Thermal and powder X-ray diffraction analysis was carried out for some crystal and microwave synthesis methods Thermal and powder X-ray diffraction analysis was carried out for some crystals. .High yield, short reaction time, pure products without purification and using only ethanol instead of toxic and expensive solvents for isolation of the products are the advantages of this method.
Keywords: quinoxaline derivatives, pharmacophore, methylene bridge formaldehyde, different pharmacological activities, enzyme inhibitor

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