Dr. Fouzia Tehseen1*, Dr. Syed Safiullah Ghori2, Saneela Sajid3, Bushra Fatima3, Naghma Fatima3, Nousheen Fatima3, Neha Samreen3, Abu Baker3
1Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana.
2Department of Pharmacology, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India.
3Students, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India.
A B S T R A C T
In today’s world of competitive research it is necessary to develop newer and greener methodologies in the field of organic synthesis. Microwave serves as an efficient tool in research studies which makes the reactions cheap, solvent free, and economic in terms of time and energy. Flavonoids are explored and have potential anti-cancer, anti-tubercular, anti-malarial, anti –inflammatory, Antioxidant, anti-infective, antiviral activities etc., because of the prescence of the chromone pharmacophore. We have developed a four steps new methodology for the synthesis of 6-amino flavanones. We started with paracetamol which was acetylated and then condensed with an aldehyde to give chalcone. Further it was converted to 6 acetamino flavanone. The acetamino group was converted to amino group to give 6 amino flavanones.
Keywords: green methodology, microwave assisted synthesis, flavonoids, amino flavanones.