Dr. Hareesh Dara*, D. Siva dinesh, Dr. Thatipelli Ravichander
The St John College of Pharmcy, Hasanparthy, Hanamkonda, Telangana
A B S T R A C T
Aim of present work was design and develop consistent and optimized formulations of Rifaximin multiparticulate targeted drug delivery to colon with the following objectives.,explore multiparticulate CDDS to achieve localized effect and evaluate the pH- sensitive polymers such as Eudragit S 100 and L100 on Rifaximin, by reducing release of drug in pH conditions of upper GI tract while enhancing the release of formulations in alkaline surroundings of the colon. Also to optimize and evaluate in-vitro release and organ distribution of dosage forms in rat model, statistical assessment of polymer ratio’s and percentage coating level interactions on drug release lag time and carry out accelerated stability studies of finalized formulations.
Keywords: Rifaximin, Multiparticulate, cdds