Wednesday , 22 May 2024

Design, Development and Optimization of Zafirlukast Press Coat Tablets for Pulsatile Drug Delivery

Sreekanth K*, Naresh G, Md Imran, Nagesh K, Hindustan Abdul Ahad 
P.G Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India

The Aim of study design and developed of press coated tablets of Zafirlukast. The drug and excipients compatibility was studied by DSC and FTIR studies. The prepared tablets were evaluated f or physicochemical properties and in vitro drug release patterns. FTIR and DSC studies revealed that there was no chemical interaction between drug and polymers used. The prepared tablets passed all physicochemical tests. The in vitro drug release pattern indicated that type of polymer and its concentration had marked influence on the drug release form tablets. The result of stability studies for the optimized formulation indicated that the formulation was stable even after stressed storage conditions.
Keywords: Zafirlukast, HPMC K100M, Press Coat tablets, pulsatile

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