Friday , 12 July 2024

Various Biological Activity of 1, 3, 4-Oxadiazole Derivatives: A Review

M Somashekhar*, R B Kotnal
Department of Pharmaceutical Chemistry, BLDEA’S College of Pharmacy, Vijaypur-586101.

Oxadiazole a heterocyclic nucleus has attracted a wide attention for the researchers in search for the new therapeutic molecules. Among them, 1,3,4-oxadiazoles have exhibited a wide range of biological properties. The first mono-substituted 1,3,4-oxadiazoles were reported in 1955 by two independent laboratories.1,3,4-oxadiazole considered as simple five membered Heterocyclic molecule possessing one oxygen and two nitrogen atoms at C-1, C-3 and C-4 respectively. 1,3,4-oxadizole exhibited a wide range of biological activities which includes antimicrobial, anti-tubercular, anticonvulsant, hypoglycemic, anti-allergic, vasodilator, anti-inflammatory, analgesic, anthelmintic, anticancer, antiviral, antioxidant, hemolytic, antiprolifrative activities etc. The purpose of this review is to collect the literature work reported by researchers on 1,3,4-oxadiazole derivatives for their various pharmacological activities and also efforts made on this moiety.
Keywords: antimicrobial, anticonvulsant, anti-inflammatory, antioxidant activities.

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