Krishna moorthy S.B*1, Sandeep. J2,Jyothirmaie. K3, Rajalakshmi.R1 1Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupathi, Andhra Pradesh, India-517102. 2Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India-51750. 3Department of Pharmaceutics, Jagan’s College of Pharmacy, Muthukur, Nellore, Andhra Pradesh, India- 524002.
Transferosomes have become increasingly apparent that vesicular drug delivery elicits modest possessions in drug targeting. Transfersomes are a form of elastic or deformable vesicle, which were first introduced in the early 1990s. Elasticity can be achieved by using an edge activator in the lipid bilayer structure. Transfersomes are applied in a non-occluded method to the skin and have been shown to permeate through the stratum corneum lipid lamellar regions as a result of the hydration or osmotic force in the skin. Transfersomes are made up of a phospholipids component along with a surfactant mixture. The ratio of individual surfactants and total amount of surfactants control the flexibility of the vesicle. The uniqueness of this type of drug carrier system lies in the fact that it can accommodate hydrophilic, lipophilic as well as amphiphilic drugs. These drugs find place in different places in the elastic vesicle before they get delivered beneath the skin. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormone, anticancer, insulin, gap junction protein, and albumin. Peripheral drug targeting, transdermal immunization can also be achieved with this type of drug delivery system.
Keywords: Transferosomes, stratum corneum, phospholipids, elasticity, transdermal.