B. Venkateswara Reddy*, S. Satyanandam
Department of Pharmaceutics, School of Pharmacy, Monad University, Hapur, U.P, India
In recent years a wide variety of newer drug delivery system like sustained/controlled release dosage forms are designed and evaluated in order to overcome the limitation of conventional therapy. These products are able to maintain steady drug plasma levels for extended periods of time as a result the variation of the drug levels in the blood are prevented and minimized drug related side effects. Controlled release drug delivery system provides a predictive control over the release pattern, and subsequent tissue or blood levels can be achieved. One of the systems which provide controlled release of drug is transdermal drug delivery systems. Depending on the therapeutic target, transdermal drug delivery systems (TDDS) are designed to provide a continuous supply of drug through the skin to allow for local or systemic drug effects. Transdermal drug delivery system (TDDS) is a novel approach for delivering drugs across the skin. Most of the drugs are administered orally and are found not to be as effective as expected. This review article describes briefly about the modes of drug administration, advantages and disadvantages of TDDS, drug penetration pathways, types of Transdermal Delivery Systems and their evaluation.
Keywords: Conventional therapy, Controlled release, Therapeutic target, Transdermal drug delivery system