Synthesis of the new carboxylic α-amino acid: 2-Benzamido-2-(1H -benzoimidazol-1-ylmethoxy) acetic acid

El Houssine Mabrouk^*1 and Abdelilah El Hallaoui^2
1Engineering, Electrochemistry, Modelling & Environmental Laboratory (LIEME), Department of Chemistry, Faculty of sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, B.P. 1796, Fez, Morocco.
²Department of Chemistry, Faculty of Sciences and Technics, BP 509 Boutalamine, Errachidia, Moulay Ismail University Meknes, Morocco.

A B S T R A C T
The present work covers the recent synthetic of 2-benzamido-2-(1H-benzoimidazol-1-ylmethoxy) acetic acid in high yield through alkaline hydrolysis reaction of methyl 2-benzamido-2-(1H-benzimidazol-1-ylmethoxy) acetate. This latter was obtained through O-alkylation reaction between methyl α-bromo glycinate N-benzoylated and 1H-benzimidazol-1-ylmethanol. The structure of the prepared compounds were determined by spectroscopic methods: ¹H-NMR, ¹³C-NMR, and MS data.
Keywords: O-alkylation, α-aminoester, α-amino acid, methyl α-bromo glycinate, alkaline hydrolysis reaction.