El Houssine Mabrouk*1 and Abdelilah El Hallaoui2
1Engineering, Electrochemistry, Modelling & Environmental Laboratory (LIEME), Department of Chemistry, Faculty of sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, B.P. 1796, Fez, Morocco.
2Department of Chemistry, Faculty of Sciences and Technics, BP 509 Boutalamine, Errachidia, Moulay Ismail University Meknes, Morocco.
A B S T R A C T
The present work covers the recent synthetic of 2-benzamido-2-(1H-benzoimidazol-1-ylmethoxy) acetic acid in high yield through alkaline hydrolysis reaction of methyl 2-benzamido-2-(1H-benzimidazol-1-ylmethoxy) acetate. This latter was obtained through O-alkylation reaction between methyl α-bromo glycinate N-benzoylated and 1H-benzimidazol-1-ylmethanol. The structure of the prepared compounds were determined by spectroscopic methods: 1H-NMR, 13C-NMR, and MS data.
Keywords: O-alkylation, α-aminoester, α-amino acid, methyl α-bromo glycinate, alkaline hydrolysis reaction.