Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, Sec-125, Noida-201303, U.P, India.
A B S T R A C T
Egg albumin nanoparticles (EANPs) are previously reported a safe and biocompatible drug carrier systems to carry out improved targeted delivery. EANPs are also low-cost and safe nanomaterials to carry out more efficient drug loading capacity to load desired drug with high site specificity and low cytotoxicity and desired delivery rate at the targeted site. Size controlling of EANPs was also done by using various methods to make them more potent nonviral carriers to carry out controlled and sustained targeted delivery of the respective biological and chemical components that bind in to them by Nanotechnology Albumin Binding Technology (nab technology). In this designed work, EANPs were prepared by using toluene driven modified emuslo-desolvation method to achieve more controllable particle size at nanoscale. DLS (Dynamic Light Scatting) was assigned to characterize the size distribution of the prepared EANPs. The prepared EANPs were found to attained size ranging from 0.5 nm to 11 nm with exhibited diameter up to 365.8 nm and width of 60.50 nm which are observed to attained narrow size distribution at nanoscale considerations. Hence, this toluene-butanol desolvation method can be used as safe and low-cost nanopractice to prepare nanosized EANPs that may further employed to carry out safe and potent drug and gene delivery as nonviral nano-therapeutic vehicles in various therapeutic applications which are going to be considered in the field of regenerative medicine, molecular medicine and nanomedicine.
Keywords: Egg albumin nanoparticles; EANPs; Emulso-Desolvation; Toluene; Dynamic Light Scattering (DLS)