Dilip B. Satpute* and Shirish S. Pingale
Abasaheb Garware College, Pune 4 (Affiliated to University of Pune), India
P.G. Department of Chemistry, Gramonnati Mandal’s Arts, Com. & Sci. College, Narayangaon, Pune-410504 (Affiliated to University of Pune), India.
The stability is aimed at assuring that the drug/drug product remains within specifications established to ensure its identity, strength, quality and purity. It can be interpreted as length of time under specific conditions and storage that a product will remain within the pre-defined limits for all its important characteristics. Each ingredient, whether therapeutically active or inactive, in a dosage form can affect stability. Environmental factors such as temperature, light, air (specifically oxygen, carbon dioxide and water vapours) and humidity can affect stability. Similarly, such factors as particle size, pH, the properties of water and other solvents employed the nature of container and the presence of other chemicals resulting from contamination or from the intentional mixing of different products can influence stability. From observations of CHNS analysis, TGA, DTG, DSC technique and HPTLC analysis of samples it was found that Alupoly is a good container closure for to store Root Bark Powder of Argemone mexicana L. The phytochemical corresponding to Rf -value 0.05 of Root Bark Powder of Argemone mexicana L. is stable at control temperature in alupoly and HDPE container closure. These results clearly indicate that there was no change in phytochemicals at accelerated conditions.
Keywords: liver tonic, ingredients, TGA, DSC, HPTLC, pH