Friday , 21 January 2022

Spectral and Antimicrobial Studies of Some r(2), c(6)-diarylpiperidin-4- one cyanoaceticacid hydrazones

S. Sivakumar1,*, R. Arulraj2, J. John Francis Xavier3, Hema Ramesh1K. Mageswari1 , A. Rajappa1 
1Department of Chemistry, Sri Manakula vinayagar Engineering College, Madagadipet,  Pondicherry-605107, India.
2Department of Chemistry, Bharathiar University, Coimbatore-641046,  India
3Department of Chemistry, Anna University campus, Panruti, India

A novel synthesis of t(3)-Methyl-r(2),c(6)-diarylpiperidin-4-onecyanoaceticacidhydrazones 1–3were synthesized and Characterized by IR,  1H and 13C NMR spectral studies. The structures were investigated for antibacterial and antifungal activity. the observed vicinal proton-proton coupling constants suggest that 1-3 adopts chair conformation with the equatorial orientations of all substituent’s. 
Keywords: piperidin-4-onecyanoaceticacidhydrazone, Spectral, antibacterial, antifungal activity

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