Saturday , 18 September 2021

Role of Dendrimers in Molecular Recognition-A Review

Author Details
Navneet Kumar Verma* and Anubha Gupta
Rameshwaram Institute of Technology and Management, Lucknow, (U.P), India

Molecular recognition refers to the interaction between molecules through without covalent bonding like hydrogen bonding, Vander Wall forces, halogen bonding, metal coordination, hydrophobic forces and, π-π interactions. Dendrimers are hyperbranched molecules which are a relatively novel class of materials with unique molecular structure and dimensions in comparison to conventional linear polymers. This review details recent notable advances in the molecular recognition in both the organic as well as inorganic components which are highly sensitive to the dendrimers. Molecular recognition has an important role in the living system such as between receptor and ligand, antigen and antibody, DNA and protein, sugar and lectin, RNA and ribosome etc. A micellar aggregate is a dynamic entity which is characterized by two distinctive layers, an inner hydrophobic core that is unsuited with the aqueous solvent, and an external hydrophilic shell. In contrast, PAMAM dendrimers are unimolecular entities, where the inner core is hydrophilic and comparatively available to the aqueous solvent.
Keywords: Molecular recognition, Dendrimers, PAMAM Dendrimers, Hydrogen bonding etc.


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