Friday , 12 July 2024

Protective Effect of Terminalia Arjuna Leaves against CCl4 Induced Hepatic Damage in Mice

B. Aruna1*, R. Venu Madhuri1, Dr. D. Madhuri1, Dr. A.V. Badrinath1, Sk. Karimulla2
1Dr. K.V. Subbareddy Institute of Pharmacy, Dupadu, Kurnool, Andhra Pradesh, India-518218.
2Department of Pharmacology, Narayana Pharmacy College, Chinthareddy Palem, Nellore, Andhra Pradesh 524003

In the present study ethanolic extract of the leaves of Terminalia arjuna was evaluated for hepatoprotective activity in carbon tetrachloride liver-damaged rats. Hepatotoxicity was induced via intraperitoneal injection of ccl4 (1:1) in olive oil, at a dose of 0.5 ml/kg body wt. Liv 52 syrup (0.5 ml/kg) was given as reference standard and exhibited significant hepatoprotection against carbon tetrachloride induced liver-damaged rats. The animals received ethanolic extract of leaves of terminalia arjuna, orally, at a dose levels of 200 and 300 mg/kg b.wt. for two weeks. terminalia arjuna has shown  significant hepatoprotection against ccl4  induced hepatotoxicity in albino rats in reducing alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST)  and levels of  total protein were investigat The extracts of the test plant exhibited significant (p < 0.05) hepatoprotective activity against the ccl4 induced liver models by improving liver function which was indicated by reduction in the levels of SGOT, SGPT, ALP, GGT, total bilirubin and total protein.

Keywords: Terminalia arjuna, ccl4, liv 52, ethanolic extract, hepatoprotective


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