D. Yashwanth Kumar*, D.S.S.N. Neelima, P. Hyma
Scientific and Applied Research Center, Hyderabad, Telangana, India
A B S T R A C T
Asthma is characterized as allergic inflammatory responses with airway hyper-responsiveness, both clinical and experimental studies suggest that eosinophils and Th2 type lymphocytes are the key role in the induction of airway inflammation and mucosal injury, The chronic inflammation is associated with airway hyper responsiveness that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing particularly at night or in the early morning. New pyrrolidinone derivatives are metalloproteinase inhibitors to be used for treating cancer, Alzheimer’s disease, asthma, rhinitis and rheumatoid arthritis. These Compounds are potent inhibitors of MMP12.
Keywords: Asthma, Rhinitis and rheumatoid arthritis, Alzheimer’s disease, cancer.