Multi-component, Catalyst free Synthesis of α-Aminonitrile by Using of Glycerol as Recyclable and Green Solvent

Amir Hossein zamani^a*, Saeedeh shariati^b, Hamid Reza Ghaieni^a
aMalekAshtar University of Technology, Tehran, Iran, 1465943681
^bAhvaz Jundishapur University of Medical Sciences. School of Pharmacy, Ahvaz, Iran, 1579461357

A B S T R A C T
We describe the use of glycerol as an efficient, safe and recyclable solvent in the one-pot reaction of aldehydes, amines, and trimethyl silylcyanide to afford corresponding α-aminonitriles in excellent yields under mild conditions. Catalyst-free, high yields, andsimple product isolation method without use of column chromatography are the noteworthy aspects of the synthetic route. Mechanistic route of the reaction proves the promoting nature of the glycerol.
Keywords: Glycerol, α-Aminonitriles, Hydrogen bonding, Strecker reaction, Multi-component reactions