Panga Latha1*, K. Umasankar1, M. Alagusundaram1, M. Srikanth Reddy1, G. Devi Nagajyothi1, M. Mallika1, Jagadesh kumar yadav.K2
1Department of pharmaceutics, Krishna Teja College of Pharmacy, Tirupathi, Andhra Pradesh, India
2Department of pharmaceutics, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andhra Pradesh, India
Amylodipine besylate is a anti-hypertensive drug (or) blood pressure reducer, having the 64% bio-availability .in the present study focus on the floating microspheres, they has been used for prolong release and rapid reaction in the stomach at a single dose frequency of administration. The present study was floating microspheres of amylodipine besylate were prepared by using solvent evaporation method with HPMC E-15. The prepared microspheres are evaluated for drug content, entrapment efficiency and in-vitro drug release. from the dissolution study F5 formulation shows more prolong drug release compare to other formulations and it showing buoyancy above 6 hrs from the results concluded that by increasing the polymer concentrations gives slower the drug release and higher the duration of drug release in stomach.
Keywords: floating microspheres, in-vitro drug release, HPMC E-15, solvent evaporation method.