D. Bargavi*, Anupam Kanti Bag, Sk. Karimulla, M. Gobinath
Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur, Muthukur, SPSR Nellore, A.P, India.
A B S T R A C T
Hepatotoxicity in one of the major parameters need to be consider in drug therapy, because most of the drugs in single at low/high doses for a prolonged period or multiple drug therapy causes liver damage. The present study aimed to investigates the possible hepatoprotective activity of ethanolic extract of curculigo orchioides (EECO) against paracetamol and ethanol induced hepatotoxicity in albino Wistar rats. Ethanolic extracts of the EECO rizomes were used in the study for determination of hepatoprotective activity against paracetamol and ethanol induced hepatotoxicity in albino Wistar rats. A comparison was also made between the actions of EECO root extracts and a known hepatoprotective drug silymarin. Preliminary phytochemical screening was carried. Biochemical parameters like SGOT, SGPT, ALP and total bilirubin and histopathological studies were used to evaluate the hepatoprotective activity. Acute toxicity studies were carried out according to OECD (420) guidelines and 400 mg/kg BW for both extracts was selected for the present study. Results showed that ethanolic extract in both the models was found to have significant hepatoprotective activity, which reduces the elevated levels of SGOT, SGPT, ALP and Total bilirubin and was almost compared to silymarin. Histopathology showed regeneration of hepatocytes to normal, with the root extracts further confirmed the hepatoprotective activity of extracts of (EECO). Thus results indicate that it is worth undertaking further studies on possible usefulness of the extracts of the roots of (EECO) in hepatotoxicity.
Keywords: Rumex vesicarius, Paracetamol, Ethanol induced hepatotoxicity in rat