Padmaja D, Hindustan Abdul Ahad, Shahin Farhana S, Sravani A, FaheemB
Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India
A B S T R A C T
The main aim of present investigation is to determine best grade of HPMC among HPMC K4M, HPMC K15M and HPMC K100M for preparing floating microspheres. The drug excipient compatibility was checked by DSC and FTIR studies. Physicochemical evaluation was performed for prepared floating microspheres was performed. Glipizide was found to be compatible with excipients used. The prepared microspheres showed good buoyancy, physicochemical characteristics and release characteristics. Among the prepared microspheres HPMC K4M was found to be better polymer for preparing Glipizide floating microspheres.
Keywords: Glipizide, microspheres, diabetes, polymer.